Objective To explore the changes of peripheral white blood cell ( WBC ) in patients with bee stings and its clinical significance. Methods A total of 133 bee sting patients were divided, according to peripheral WBC counts, into groups A(WBC≤Sl0×l09/L, n=25), B ( 10 ×l09/L < WBC≤20×109/L, n = 66 ) and C ( WBC >20 × 109/L, n=42). The levels of tumor necrosis factor - α( TNF - α ), interleukin hormone ( IL ) - 6, IL - 8, hemoglobin ( Hb ), platelet count ( PLT ), serum lactate dehydrogenase ( LD ), serum creatine kinase ( CK ), Aspartate aminotransferase ( AST ), the Alanine aminotransferase ( ALT ), serum albumin ( ALB ), total bilirubin ( STB ) and blood creatinine ( Scr ) were detected. Results There was significant difference in numbers of wasp stings and levels of TNF - α, IL - 6, IL - 8 between 3 groups on admission ( P <0. 01 ). No significant difference in Hb, PLT, ALB, Scr on days 7 after admission ( P >0. 05 ). There was difference in LD, CK, AST, ALT, STB ( P <0. 01 ). Conclusion WBC, an early sensitive indicator for systemic inflammatory response syndrome ( SIRS ) caused by acute bee stings and closely correlated with damages of organ functions, can be recommended as one of the evaluating indicators for severity of acute bee sting patients.%目的 探讨急性蜂蜇伤患者外周血白细胞计数水平的变化及其临床意义.方法 选择2008年8月-2011年10月我院确诊的急性黄蜂蜇伤患者133例,根据外周血白细胞计数(WBC)水平分为3组:WBC≤10×109/L(A组,25例)、10×109/L＜WBC≤20×109/L (B组,66例)、WBC＞20×109/L (C组,42例).检测所有患者肿瘤坏死因子α(TNF-α)、白介素(IL)-6、IL-8、血红蛋白(Hb)、血小板计数(PLT)、乳酸脱氢酶(LD)、磷酸肌酸激酶(CK)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、血清清蛋白(ALB)、总胆红素(STB)及血肌酐(Scr)水平.结果 入院时3组患者蜂蛰伤针眼数及TNF-α、IL-6、IL-8水平比较,差异均有统计学意义(P＜0.01).入院第7天3组患者Hb、PLT 、ALB、Scr水平比较,差异均无统计学意义(P＞0.05);3组患者LD、CK、AST、ALT、STB水平比较,差异均有统计学意义(P＜0.01).结论 WBC是评价急性蜂蜇伤所致全身炎症反应综合征(SIRS)严重程度的早期敏感指标,且与器官功能损害密切相关,可推荐为早期判断急性蜂蜇伤患者病情严重程度的指标之一.
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