miRNA-196a2 rs116149131基因多态性与胃癌患病风险的Meta分析

摘要

Objective To evaluate the association between the microRNA ( miRNA)⁃196a2 rs116149131 gene polymorphism and susceptibility of gastric cancer. Methods All studies published up to March 2016 on the association between miRNA⁃196a2 rs116149131 gene polymorphism and susceptibility to gastric cancer were searched from PubMed, EMBASE, Cochrane library, CNKI, VIP, Wan fang and CBD database. The data were screened according to the inclusion and exclusion criteria, and extracted, and the quality of included studies was evaluated.The pooled odds ratios (OR) with 95% confidence intervals (95%CI) were calculated using Stata 12�0 software.Publication bias and sensitivity analysis were also assessed. Results A total of 9 studies involving 3992 cases and 5699 controls were included in the meta⁃analysis. The present meta⁃analysis showed no association between the miRNA⁃196a2 rs116149131 gene polymorphism and gastric cancer risk. In ethnic subgroup analysis, a strong association in heterozygous model ( CT vs. TT:OR=1�93, 95%CI:1�35⁃2�75, P<0�05) was found between rs11614913 and gastric cancer risk among Caucasians but no as⁃sociation in all models was found among Asians. In source of controls subgroup analysis, no association was found between rs11614913 and cancer risk among population⁃based (PB) and hospital⁃based (HB).In the subgroup of TC. Conclusion miRNA⁃196a2 rs116149131 gene polymorphism and gastric cancer has no risk associated,but there are racial differences.%目的：探讨microRNA（ miRNA）⁃196a2 rs116149131基因多态性与胃癌易感性的关系。方法计算机检索PubMed、EMBASE、Cochrane library、中国知网、维普、万方及中国生物医学文献（ CBD）等数据库中2016年3月1日之前关于miRNA⁃196a2 rs116149131基因多态性与胃癌易感性的相关研究。按纳入与排除标准筛选文献、提取资料并评价纳入研究的质量后，采用Stata 12�0软件进行Meta分析，计算合并OR值及其95％CI，并进行发表偏倚评估及敏感性分析。结果共纳入9篇文献，包括3992例患者和5699例对照。 Meta分析结果显示，miRNA⁃196a2 rs116149131基因多态性与胃癌易感性无明显相关性。按种族进行亚组分析结果显示，rs116149131基因多态性在杂合子模型中显著增加高加索人种胃癌患病风险（ CT vs． TT：OR＝1�93，95％CI：1�35～2�75，P＜0�05）；而在亚洲人种中未发现该位点多态性与胃癌易感性有关。根据对照组人群的来源进行亚组分析结果显示，在以医院和以人群为基础的研究中均未发现有与胃癌易感性相关的等位基因或者基因型。在T＜C亚组中，显性基因模型（ CT＋CC vs． TT：OR＝1�40，95％CI：1�10～1�77，P＝0�005）、纯合子模型（ CC vs． TT：OR＝1�59，95％CI：1�22～2�06，P＝0�001）和杂合子模型（ CT vs． TT：OR＝1�33，95％CI：1�04～1�70，P＝0�025）中发现rs116149131基因多态性与胃癌患病风险存在关联性；在等位基因模型和隐性基因模型中并未发现关联性。在T＞C组未发现rs116149131多态性与胃癌患病风险存在关联性。结论 miRNA⁃196a2 rs116149131基因多态性与胃癌患病风险无关联性，但存在种族差异。