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METHOD FOR DIAGNOSING AFFECTION RISK OF PROSTATIC DISEASE USING NEW GENE POLYMORPHISM
METHOD FOR DIAGNOSING AFFECTION RISK OF PROSTATIC DISEASE USING NEW GENE POLYMORPHISM
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机译:新基因多态性诊断前列腺疾病患病风险的方法
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摘要
PROBLEM TO BE SOLVED: To obtain gene polymorphism useful for diagnosing a prostatic disease such as prostate cancer, prostatomegaly, etc., or its affection risk and to provide a diagnostic method and a diagnostic kit using the same.;SOLUTION: The single nucleotide polymorphism of HPC2/ELAC2 has a specific human-derived base sequence. The polynucleotide is useful for identifying the single nucleotide polymorphism of the HPC2/ELAC2. The method for diagnosing the prostatic disease or its affection risk comprises identifying the single nucleotide polymorphism of HPC2/ELAC2. The kit for diagnosing the prostatic disease or its affection risk contains a reagent for identifying the single nucleotide polymorphism of the HPC2/ELAC2. The gene polymorphism of codon 627 is not found in Caucasian species and has high possibility of gene polymorphism characteristic of the yellow-skinned races, especially of Japanese. Consequently the prostatic disease or its affection risk of the yellow-skinned races, especially Japanese, which is not diagnosed by a method using known codon 541, is diagnosed using the codon 627.;COPYRIGHT: (C)2004,JPO
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