我院心血管内科老年患者潜在药物相互作用导致药物不良事件的影响因素分析

摘要

目的:为减少不利的药物相互作用(DDI)、避免药物不良事件(ADE)的发生提供参考.方法:选择2015年6月-2016年3月我院心血管内科年龄大于65岁的患者,研究其潜在的药物相互作用(PDDI)导致ADE的影响因素,通过多因素Logistic回归分析相关因素与PDDI导致ADE发生的关系.结果:共纳入328例患者,其中有PDDI的患者共257例,PDDI共计452例次(包括轻微的PDDI 247例次,一般的PDDI 149例次、严重的PDDI 56例次).患者年龄、同时使用的药物数、肌酐清除率、肝功能(Child-Pugh评分)与PDDI导致ADE的发生有关(P<0.01).结论:对于PDDI引起的ADE,可以对患者年龄、同时使用的药物数、肌酐清除率、肝功能因素等进行风险评估,风险评估的高危患者应当提前干预,降低患者发生ADE的风险.%OBJECTIVE: To provide reference for reducing disadvantageous drug-drug interaction(DDI)and avoiding adverse drug event(ADE). METHODS: The patients aged more than 65 were selected from cardiovascular department in our hospital dur-ing Jun. 2015-Mar. 2016. The influential factors for potential DDI(PDDI)-induced ADE were analyzed. The relationship of related factors with PDDI-induced ADE was analyzed by multivariate Logistic regression analysis. RESULTS:A total of 328 patients were included,involving 257 PDDI patients,and totally 452 cases of PDDI (including 247 cases of mild PDDI,149 cases of general PDDI and 56 cases of severe PDDI). The age,the number of drugs used simultaneously,Ccr and liver function (Child-Pugh score)were related to the occurrence of PDDI-induced ADE(P<0.01). CONCLUSIONS:For PDDI-induced ADE,the risk evalua-tion can be conducted for a series of factors,including age,the number of drugs used simultaneously,Ccr and liver function. For high-risk patients,intervene should be conducted in advance to reduce the risk of ADE.