美托洛尔联合参松养心胶囊治疗室性早搏的临床观察

摘要

OBJECTIVE:To observe therapeutic efficacy and safety of metoprolol combined with Shensong yangxin capsule in the treatment of ventricular premature beat. METHODS:A total of 104 patients with ventricular premature beat during Jan. 2016-Jan. 2017 were analyzed retrospectively,and they were divided into control group(52 cases)and observation group(52 cases)according to medication plan. Control group was given Metoprolol tartrate tablet 25 mg orally,3 times a day. Observation group was given Shensong yangxin capsule 1.2 g orally,3 times a day,on the basis of control group. Both groups were treated for consecutive 28 d. Clinical efficacies of 2 groups were observed. The electrocardiogram P-R interval and Q-T interval,24 h premature beat times,heart rate,the occurrence of palpitation before and after treatment and ADR were observed. RESULTS:Total response rate of observation group(92.30%)was significantly higher than that of control group(76.92%),with statistical significance(P0.05). After treatment,electrocardiogram P-R interval and Q-T interval of 2 groups were significantly higher than before treatment,and the observation group was significantly higher than the control group. 24 h premature beat times,palpitation times of 2 groups and heart rate of control group were significantly lower than before treatment;and 24 h premature beat times,palpitation times of the observation group was significantly lower than the control group,with statistical significance(P0.05). There was no statistical significance in the total incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:For ventricular premature beat,metoprolol combined with Shensong yangxin capsule show significant therapeutic efficacy,can reduce the times of premature beat and improve patients'electrocardiogram without increasing the occurrence of ADR.%目的:观察美托洛尔联合参松养心胶囊治疗室性早搏的疗效和安全性.方法:回顾性分析2016年1月-2017年1月收治的104例室性早搏患者资料,按用药方案的不同分为对照组(52例)和观察组(52例).对照组患者给予酒石酸美托洛尔片25 mg,口服,每日3次;观察组患者在对照组治疗的基础上给予参松养心胶囊1.2 g,口服,每日3次.两组均连续治疗28 d.观察两组患者的临床疗效,治疗前后心电图P-R间期、Q-T间期、24 h早搏次数、心率、心悸发生情况及不良反应发生情况.结果:观察组患者总有效率(92.30%)显著高于对照组(76.92%),差异有统计学意义(P0.05).治疗后,两组患者心电图P-R间期、Q-T间期均显著高于同组治疗前,且观察组显著高于对照组;两组患者24 h早搏次数、心悸次数及对照组患者心率均显著低于同组治疗前,且观察组24 h早搏次数、心悸次数显著低于对照组,差异均有统计学意义(P0.05).两组患者不良反应总发生率比较,差异无统计学意义(P>0.05).结论:美托洛尔联合参松养心胶囊治疗室性早搏疗效显著,可减少早搏次数,且未增加不良反应的发生.