1吡美莫司联合2.5二硫化硒洗剂治疗头部脂溢性皮炎的临床效果观察

摘要

Objective To observe the clinical effect of 1% pimecrolimus cream combined with 2.5% selenium sulfide lotion in the treatment of seborrheic dermatitis on scalp. Methods 82 patients with seborrheic dermatitis on scalp ad-mitted into our hospital fromJuly 2012 to December 2013 were selecte and randomly divided into treatment group(n=42) and control group (n=40) by in treatment order from first to last.Two groups were given 2.5% selenium sulfide lotion.At the same time,treatment group was externally given 1% pimecrolimus cream,control group was externally given 0.1%halcinonide solution.Scalp itch,erythema,desquamation and adverse drug reaction in two groups was observed,and total effective rate and recurrence rate was compared between two groups. Results After 4 weeks of treatment,the total effec-tive rate in treatment grou was 92.9%,in control group was 87.5%,there was no statistical significance (χ²=0.67,P>0.05). Treatment period,there was no significant difference in the incidence of adverse reactions between two groups (P>0.05). Follow-up 1 month after discontinuation,the relapse rate in the treatment group was 9.5%,which was significantly lower than that in the control group(27.5%),and the difference between the two groups was statistically significant(χ²=4.43,P<0.05). Conclusion 1% pimecrolimus cream combined with 2.5% selenium sulfide lotion in the treatment of seborrheic dermatitis on scalp has a high effective rate and low relapse rate, which is worthy of clinical promotion.%目的：观察1%吡美莫司乳膏联合2.5%二硫化硒洗剂治疗头部脂溢性皮炎的临床效果。方法选取2012年7月~2013年12月于本院门诊就诊的82例头部脂溢性皮炎患者,将其按就诊先后顺序随机分为治疗组(n=42)和对照组(n=40)。两组均采用2.5%二硫化硒洗剂,同时治疗组外涂1%吡美莫司乳膏,对照组外涂0.1豫哈西奈德溶液。观察两组头皮瘙痒、红斑和脱屑变化情况及药物不良反应,并对比两组的治疗总有效率和复发率。结果治疗4周后,治疗组的治疗总有效率为92.9%,对照组为87.5%,差异无统计学意义(字2越0.67,孕跃0.05)。治疗期间,两组的不良反应发生率差异无统计学意义(P>0.05)。停药1个月后随访,治疗组的复发率为9.5%,显著低于对照组的27.5%,两组差异有统计学意义(字2越4.43,孕<0.05)。结论1豫吡美莫司乳膏联合2.5%二硫化硒洗剂治疗头部脂溢性皮炎的有效率高、复发率低,值得临床推广。