目的 了解北京城区长期服用非甾体消炎药(NSAID)患者幽门螺杆菌(Hp)感染现状,分析Hp感染的影响因素.方法 对190例北京城区长期服用NSAID患者行13C尿素呼气试验检查,统计Hp感染的比例,记录入选者的年龄、性别、吸烟史、饮酒史、文化程度、在职情况、胃炎及消化性溃疡家族史、饮食习惯资料,分析其与Hp感染的关系.结果 190例患者中,Hp阳性102例,占53.7%,阴性88例,占46.3%.不同年龄、在职情况、胃炎及消化性溃疡家族史和饮食习惯的患者Hp感染比例差异有统计学意义[<40岁:60.0%(30/50),40~65岁:59.1% (52/88),>65岁:38.5% (20/52);在职:80.0% (80/100),不在职:24.4% (22/90);有胃炎及消化性溃疡家族史:86.0%(74/86),无胃炎及消化性溃疡家族史:27.0% (28/104);饮食规律:25.5% (28/110),饮食不规律:92.5% (74/80)] (P <0.05).结论 北京城区长期服用NSAID患者Hp感染与年龄、在职情况、胃炎及消化性溃疡家族史及饮食习惯明显相关.%Objective To analyze the status and influence factors of helicobacter pylori (Hp) infection in patients taking non-steroidal antiinflammatory drugs (NSAID) in Beijing.Methods One hundred and ninety outpatients with long term usage of NSAID in Beijing were enrolled and underwent 13C-urea breath test (13 C-UBT).The proportion of Hp infection was calculated; the correlations of age,sex,smoking history,drinking history,education degree,working condition,family history of gastritis and peptic ulcer,dietary habits with Hp infection were analyzed.Results Among these 190 patients,there were 102 Hp positive patients (53.7%) and 88 Hp negative patients (46.3%).The infection rate of Hp was significantly different among patients with different ages,working conditions,family history of gastritis and peptic ulcer disease,dietary habits [< 40 years old:60.0% (30/50),40-65 years old:59.1% (52/88),>65 years old:38.5% (20/52) ; working:80.0% (80/100),not working:24.4% (22/90) ; positive family history:86.0% (74/86),negative family history:27.0% (28/104); regular diet:25.5% (28/110),irregular diet:92.5% (74/80)] (P < 0.05).Conclusion The Hp infection in patients taking NSAID drugs for long time in Beijing is significantly related to age,working conditions,family history of gastritis and peptic ulcer and diet habits.
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