尼可地尔对冠脉慢血流患者肱动脉血流介导的内皮依赖性血管舒张功能影响

摘要

目的探讨尼可地尔对冠状动脉慢血流（CSF）患者肱动脉血流介导的内皮依赖性血管舒张功能（FMD）影响。方法经冠脉造影诊断为CSF患者120例，根据治疗方法分为对照组（n=60）与尼可地尔组（n=60）。对照组给予常规治疗，尼可地尔组给予常规治疗加尼可地尔治疗。于治疗前、治疗后3个月分别检测FMD、APN、hsCRP的水平。结果尼可地尔组患者的FMD较治疗前明显改善（P＜0.05），APN较治疗前升高（P＜0.05），hsCRP较治疗前降低（P＜0.05），且ΔFMD与ΔAPN呈正相关、与ΔhsCRP呈负相关。常规治疗组的FMD、APN、hsCRP治疗前后差异无统计学意义（P＞0.05）。结论尼可地尔能显著增加CSF患者FMD，改善内皮功能。%Objective To investigate the effect of nicorandil on endothelial-dependent flow-mediated vasodilation(FMD) of the brachial artery in patients with coronary slow flow(CSF). Methods 120 patients with CSF were enrolled and randomized divided into control group(n=60)and nicorandil group(n=60). Control group patients were administrated of conventional treatment,nicorandil group were administrated of nicorandil on the basis of conventional treatment. The levels of FMD,APN,hsCRP were measured before and three months after treatmeat. Results Compared with before treatment,FMD improved in nicorandil groups after treatment(P < 0.05),APN level increased(P < 0.05) whereas hs-CRP level decreased(P < 0.05);changes of FMD was positively correlated with changes of APN,and was negativly correlated with changes of hs-CRP. FMD,APN and hs-CRP in control group had no significantly changes after 3 months' treatment. Conclusion Nicorandil can improve the FMD of the brachial artery in patients with CSF.