目的 探讨血浆同型半胱氨酸(HCY)水平与血管性痴呆(VD)的相关性.方法 按诊断标准将我院脑梗死住院患者分别纳入VD 组(78例)和非痴呆组(202例),另选取同期同龄正常体检者100例为对照组.检测并比较三组间的HCY 浓度,并借助简易精神状态速检表(MMSE)对VD 组进行痴呆程度分类,分析其与HCY 之间的关系.结果 VD 组和非痴呆组的HCY 浓度均高于对照组,且以VD 组最高(P < 0.05);随着痴呆程度的加重,MMSE 评分逐渐降低,HCY 的浓度则逐渐升高,MMSE 评分和HCY 浓度二者之间呈负相关(r = -0.703,P<0.05).结论 深化HCY与VD 关系的认识,监测HCY 浓度,有利于VD 的防治.%Objective To study the correlation between plasma homocysteine (HCY) levels and vascular dementia (YD). Methods According to diagnostic criteria, 78 cases of VD patients (VI) group), 202 cases of patients with non-demented cerebral infarction (non demented group} and 100 normal healthy persons (control group) in our hospital were recruited in the study. Their total plasma HCY levels were measured with enzymatic cycle detection. The severity of cognition impairment in VD patients was classified by mini-mental state examination (MMSE) scores. The relationship between MMSE's scores with HCY concentrations was analyzed. Results The mean of plasma HCY concentrations in the YD group and non-demented group were higher than that in the control group, and was highest in the VI) group (P < 0.05). MMSE scores was decreased and plasma HCY concentrations were increased with the severity of dementia, and there were negative correlation ir - -0.703, P< 0.05) between MMSE scores and plasma HCY concentrations. Conclusion To deepen the relationship of HCY and VD, and monitor HCY concentration, which are conducive to prevention and treatment of VD.
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