阿托伐他汀联合二甲双胍治疗老年2型糖尿病伴血脂异常的效果

摘要

Objective To investigate effect of Atorvastatin combined with Dimethylbiguanide in treating elderly type 2 diabetes with dyslipidemia.Methods The clinical data of 280 cases of elderly patients diagnosed as type 2 diabetes with dyslipidemia in Chengyang People's Hospital from January 2014 to January 2017 was analyzed,they were divided into two control group (Atorvastatin) and observation group (Atorvastatin combined with Dimethylbiguanide),with 140 cases in each group.The levels of fasting blood glucose (FBG),postprandial blood glucose (PBG),glycosylated hemoglobin (HbA1c),fasting insulin (Fins),insulin resistance (HOMA-IR),triacylglycerol (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterin (LDL-C) of two groups were detected before and after treatment.The clinical effects of the two groups were observed.Results The levels of FBG,PBG,HbA1c,Fins,HOMA-IR,TG,TC,HDL-C,LDL-C between two groups had no significant differences before treatment (P ＞ 0.05).After treatment,the levels of FBG,PBG,HbA1c,Fins,HOMA-IR,TG,TC,LDL-C in the two groups were all significantly lower than those before treatment,while the levels of HDL-C were higher than those before treatment (P ＜ 0.05).After treatment,the levels of FBG,PBG,HbA1c,Fins,HOMA-IR,TG,TC,LDL-C of observation group were lower than those of control group,while the level of HDL-C was higher than that of control group (P ＜ 0.05).The total effective rate of observation group was higher than that of control group,the difference was statistically significant (P ＜ 0.05).Conclusion Atorvastatin combined with Dimethylbiguanide in treating elderly type 2 diabetes with dyslipidemia can significantly improve the levels of blood glucose and blood lipid,the clinical efficacy is remarkable and it is worthy of promotion and application.%目的 探讨阿托伐他汀联合二甲双胍治疗老年2型糖尿病伴血脂异常的效果.方法 分析青岛市城阳人民医院2014年1月～2017年1月确诊的280例老年2型糖尿病伴血脂异常患者的临床资料,依据治疗方式的不同分为对照组(二甲双胍)、观察组(阿托伐他汀联合二甲双胍治疗),各140例.测定两组患者治疗前后空腹血糖(FBG)、餐后2h血糖(PBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(Fins)、胰岛素抵抗(HOMA-IR)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)情况,观察两组患者临床疗效.结果 两组2型糖尿病伴血脂异常患者治疗前FBG、PBG、HbA1c、Fins、HOMA-IR、TG、TC、HDL-C、LDL-C比较差异均无统计学意义(P＞0.05),两组治疗后FBG、PBG、HbA1c、Fins、HOMA-IR、TG、TC、LDL-C均低于同组治疗前,HDL-C高于同组治疗前,差异有统计学意义(P＜0.05).观察组治疗后FBG、PBG、HbA1c、Fins、HOMA-IR、TG、TC、LDL-C均低于对照组,HDL-C高于对照组,差异有统计学意义(P＜0.05).观察组总有效率高于对照组,差异有统计学意义(P＜0.05).结论 阿托伐他汀联合二甲双胍治疗老年2型糖尿病伴血脂异常患者能明显改善血糖水平和血脂水平,临床效果良好,值得推广应用.