后装调强放疗计划系统的软件实现

摘要

Objective To develop an inverse planning system for afterloading brachytherapy with computer programming.Methods Based on VC++ programming, the afterloading source applicator were reconstructed on a series of CT images of a patient with cervical cancer and then several stationary points which should be used in intensity-modulated optimization process were automatically activated. Then the activation time of these stationary points was calculated inversely with simulated annealing algorithm to implement the intensity-modulated optimization of afterloading dose. Then the afterloading dose and external irradiation dose were fused with 3D image registration technology as well as the dose distribution of the patient underwent internal and external irradiation was evaluated with equivalent dose in 2Gy/f (EQD2).Results The optimal afterloading therapy schedule in line with clinical requirements can be found inversely with the system which can give consideration to both of absorbed dose of target regions and limited radiation dose of vital organs.Conclusion The system with proprietary intellectual property rights can basically meet the individualized requirements of afterloading brachytherapy.%目的：通过计算机编程，自主开发一套后装调强放疗计划系统。方法以VC++为编程工具，读取一套宫颈癌患者的CT图像；在CT图像上重建后装施源器，根据靶区器官的限量约束条件，自动激活需参与调强优化的驻点，以模拟退火算法逆向计算被激活驻点的时间，实现后装剂量的调强优化；再应用三维图像配准技术融合后装剂量与外照射剂量，以等效剂量EQD2评估患者经内外照射后的剂量分布。结果该系统能同时兼顾靶区受量和重要器官限量，逆向寻找出一种最佳的符合临床治疗要求的后装治疗方案。结论本系统具有自主知识产权，可基本满足个体化后装治疗的需求。