（O，O）-二烷基-α-苯基-α-（4-取代芳甲酰氨基）-甲基膦酸酯的合成与波谱表征

摘要

A series of (O ,O)‐dialkyl‐α‐phenyl‐α‐(4‐substituted benzoylamino) methylphospho‐nate were synthesized from α‐aminophosphonate and 4‐substituted benzoic acid chloride under ice bath .The products were characterized by elemental analysis ,IR ,NMR (1 H NMR ,13 C NMR and 31 P NMR) and mass spectrometry .In order to further confirmed the structure of these compounds ,4f ,4g ,4i ,4j ,4k and 4l were determined by X‐ray diffractometer .The proto‐nated molecules [M + H ]+ of compounds 4a - 4f were analyzed under electrospray ionization tandem mass spectrometric conditions ,at the same time ,attempts were made to explain the possible mechanism of the formation of rearrangement ion .%通过（O ，O）‐二烷基‐α‐苯基‐α‐氨基亚膦酸酯与4‐取代芳基甲酸的缩合反应合成了12种目标化合物，产物结构利用元素分析、红外光谱、核磁共振（1 H NMR 、13 C NMR 和31 P NMR）光谱和质谱进行了表征。为了进一步了解此类化合物的结构，利用 X 射线单晶衍射测定了化合物4f ，4g ，4i ，4j ，4k 和4l 的单晶结构。分析了化合物4a －4f 加氢离子的电喷雾多级质谱裂解规律，解释了重排离子 r 形成的可能机制。