A PROCESS FOR THE SYNTHESIS OF ANTIFILARIAL 1-SUBSTITUTED A PROCESS FOR THE SYNTHESIS OF ANTIFILARIAL 1-SUBSTITUTED A PROCESS FOR THE SYNTHESIS OF ANTIFILARIAL 1-SUBSTITUTED 4-CARBAMOYLPIPERAZINES 4-CARBAMOYLPIPERAZINES 4-CARBAMOYLPIPERAZINES

摘要

A process for the synthesis of 1-substituted 4-carbamolypiperazines of the general formula I.wherein RSUB1/SUB is hydrogen or an alkyl radical like methyl, ethyl, propyl or an aryl radical like phenyl or an aralkyl radical like benzyl and N(R)SUB2/SUB is a heterocyclic nucleus such as pyrrolidyl,involving the condensation of 1-substituted piperazinecarbonyl chlorides (prepared from 1-substituted piperazine and phosgene by methods essentially known in literature) with heterocyclic amines such as pyrrolidine in solvents like benzene in presence of a base like triethylamine.