Mg(ClO4)2催化2-取代-4-甲酰基-1,2,3-三唑与β-环己二酮的缩合反应

摘要

在Mg(ClO4):催化下,2-取代-4-甲酰基-1,2,3-三唑代替传统的芳香醛与β-环己二酮在乙腈介质中进行缩合反应生成氧杂葸,反应时间为5～6 h,产率75%～86%.该方法具有操作简便、反应时间短及产率高等优点,为此类化合物的合成提供了一种有效的新方法.在没有催化剂的体系中,反应生成的是氧杂蒽开环产物.%The condensation reaction of 2-substituted-4-formyl-1,2,3-triazole instead of the ordinary aldehydes with β-cyelohexanedione was investigated by acrylonitrile as a reaction medium, employing Mg( C104)2 as the catalyst. It was found that when the reaction was carried out in the presence of Mg( Cl04 ) 2, xanthenes was obtained. The reaction time was 5-6 h, and the yield ranged from 75％ to 86％. This method has many advantages in the organic synthesis process, such as simple operation, short reaction time, and high yields,which afforded an effective method to synthesize the xanthenes. Further study show that this reaction could give xanthenediones ring-opening derivatives without additional catalyst.