Macrophages’M1 or M2 by tumor microparticles:lysosome makes decision

摘要

Cells deliver messages to their surroundings or distant cells by secreting signaling molecules or releasing extracellular microvesicles(EVs)[1,2].Two types of EVs have been identified:exosomes and microparticles(MPs),which are also termed microvesicles(MVs).Exosomes are endosome-derived EVs(30-100 nm)that deliver information about proteins,mRNAs,and microRNAs to recipient cells[3].MPs are plasma membrane-derived shedding vesicles with sizes ranging from 0.1 to 1μm[4].