核因子-кB(NF-кB)作为一种重要的转录因子在通常情况下对心肌细胞起保护作用,但在不同的刺激下,NF-кB表现出的作用不尽相同.NF-кB参与心血管疾病病理过程的多个环节,包括细胞生存、增殖和分化,调节细胞对各种刺激的反应,如低氧、压力和缺血等.NF-кB在众多心血管疾病如动脉粥样硬化、心肌缺血再灌注损伤、缺血预处理、心肌肥大和心力衰竭等的发生和发展中发挥重要作用.%Nuclear factor-kappa B (NF-KB) acts as one kind of important transcription factors to play the protective function to the myocardial cell in physiological state, but the function of NF-kB is different based on stimulation.NF-kB has been shown to influence multiple segments during the numerous cardiovascular diseases pathological process, including cell survival, appreciation and differentiation, adjustment of cell response to each kind of stimulations, such as hypoxia, pressure and ischemia and so on. NF-kB plays an important role in numerous cardiovascular diseases such as atherosclerosis, the myocardial ischemia reperfusion injury, the ischemic preconditioning,the myocardial hypertrophy and the heart failure.
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