脂毒性与胰岛微血管内皮细胞损伤的研究进展

摘要

Islet microcvascular endothelial cells play a critical role in islet endocrine function and pathogenesis of diabetes. Excessive lipotoxicity can cause these cells injury and dysfunction of pcells directly by inducing oxidative stress, vasomotor dysfunction and cell apoptosis.%胰岛微血管内皮细胞作为胰岛微循环系统最主要的组成成分,直接参与糖尿病胰岛功能衰竭的发生发展过程.脂毒性损伤可通过促进内皮氧化应激、影响血管舒缩功能、诱导细胞凋亡等多种途径直接破坏胰岛微循环内皮细胞,影响胰岛细胞功能.