跨损伤合成DNA聚合酶ζ-Rev7在肿瘤发展中的研究进展

摘要

跨损伤DNA合成(TLS)属于一种复制后修复过程,主要涉及DNA聚合酶κ、η和ζ等.跨损伤修复是细胞内一种DNA损伤耐受机制,DNA聚合酶ζ在这一过程中扮演着重要的角色,DNA聚合酶ζ主要由亚基Rev7和Rev3构成,在细胞代谢中的作用主要是参与跨损伤修复.Rev7(也称为MAD2L2)是一种多功能蛋白,能够与多种蛋白结合,参与DNA损伤修复、细胞的周期调节、基因表达和致癌作用.同时也参与调控多种不良肿瘤的预后过程.%Translesion DNA synthesis is a kind of post-replication repair process, which mainly involves DNA polymerase kappa, eta and zeta.Translesion synthesis is a tolerance mechanism of DNA damage inside the cell, in which DNA polymerase zeta plays an important role.DNA polymerase zeta is mainly composed of subunits Rev7 and Rev3, and play a main role of participate in the damage repair in cell metabolism.Rev7(also known as MAD2L2)is a multifunctional protein that can be combined with a variety of proteins to participate in DNA dam-age repair, cell cycle regulation, gene expression and carcinogenesis, which is also involved in the prognosis of various adverse tumors.