目的探讨 CP 化疗方案对卵巢癌患者血清 IL-2及 CA125水平的影响.方法将2009年10月~2011年6月在本院接受 CP 方案化疗的38例卵巢癌患者作为研究对象,并以同期在本院进行体检的40例健康女性作为对照,采用酶联免疫吸附法(ELISA)检测受试者血清中的 IL-2及 CA125的含量.结果化疗前,卵巢癌患者血清中 IL-2含量显著低于对照组,CA125含量显著高于对照组(P<0.05)；而化疗后,卵巢癌患者血清中 IL-2含量较化疗前显著升高,CA125含量较对照组显著降低,两者与对照组比较均无统计学差异(P>0.05).CP 化疗方案治疗卵巢癌的有效率为96.4%,且疗效与患者血清 IL-2及 CA125水平显著相关,治疗效果越好,血清中 IL-2水平越高,血清 CA125水平越低.结论 CP 化疗方案治疗卵巢癌患者的效果较好,可能与影响患者血清 IL-2及 CA125的水平有关.% Objective To investigate the effects of CP chemotherapy regimen on the serum IL-2 and CA125 levels in patients with ovarian cancer. Methods 38 cases of patients with ovarian cancer who were treated by CP chemotherapy regi-mens from October 2009 to June 2011 in our hospital were selected as research group, and 40 cases of healthy people ex-amined in our hospital at the same time were chosen as the control group, the serum IL-2 and CA125 levels of two groups were detected by using enzyme-linked immunosorbent method (ELISA). Results Before Chemotherapy, the serum IL-2 content of ovarian cancer patients was significantly lower than that in the control group, but the serum CA125 content was significantly higher(P<0.05). After chemotherapy, the serum IL-2 content of ovarian cancer patients was significantly higher than that before treatment, while the serum CA125 content was significantly lower than that before treatment(P<0.05). No significant difference was observed in serum CA125 and IL-2 content between the two groups after chemotherapy (P>0.05). The total effective rate of CP chemotherapy on the ovarian cancer was 96.4%, which was significantly related to the serum IL-2 and CA125 levels. The better efficacy, the higher the serum IL-2 level was and the lower serum CA125 level. Conclu-sion CP chemotherapy was effective in the treatment of ovarian cancer. The serum IL-2 and CA125 level may be involved in the efficacy of CP chemotherapy.
展开▼
