幽门螺杆菌感染与胃食管反流的关系

摘要

目的 探讨胃食管反流病(GRED)与幽门螺杆菌(Hp)的关系.方法 确诊的胃食管反流病患者60例及浅表糜烂性胃炎患者63例(对照组),均行幽门螺杆菌检测,再将60例GERD患者分为2组,25例常规三联抗HP治疗,为HP根除组,另外35例作为Hp持续感染组.随访1年.结果 60例GERD患者Hp感染率为58.3%,对照组Hp感染率82.5%,GERD患者Hp感染率低于对照组,差异有统计学意义(P＜0.05).Hp根除组GERD复发率高于Hp持续感染组,差异有统计学意义(P＜0.05).对照组Hp根除后GERD的发病率为25.5%.结论 Hp感染可能在GERD的发病过程中起保护作用.%Objective To explore the relationship between gastroesophageal reflux disease( GRED )and Helicobacter pylori( Hp ). Methods Helicobacter pylori was checked among the patients ,60 cases of Gastroesophageal reflux disease( GRED )and 63 cases of the superficial erosive gastritis. The 60 cases of Gastroesophageal reflux disease were divided into two groups. Helicobacter pylori eradicate group ( 25 cases )had routine trigeminy resist treatment of Helicobacter pylori,the other 35cases as persistent infection of Helicobacter pylori group. Follow up was conducted of one year. Results The Helicobacter pylori infection rate of 60 cases of Gastroesophageal reflux dis-ease( GRED )was 58. 3 percent. The Helicobacter pylori infection rate of 63 cases of control group was 82. 5 percent. The Helicobacter pylori infection rate of Gastroesophageal reflux disease group was lower than that of control group. The difference between two groups had statistical significance( P < 0.05 ). The GRED relapse rate of Helicobacter pylori eradication group was higher than that of persistent Helicobacter pylori infection group. The difference between two groups had statistical significance( P <0. 05 ). The GERD morbidity of control group after Helicobacter pylori eradication was 25. 5 percent. Conclusion Helicobacter pylori infection may play the protective effect in the occurrence of Gastroesophageal reflux disease.