氟哌噻吨美利曲辛改善经皮冠状动脉介入术后病人的焦虑抑郁及预后

摘要

目的 评价氟哌噻吨美利曲辛对经皮冠状动脉介入治疗(PCI)病人的术后焦虑及抑郁改善及其预后效果.方法 选择成功接受PCI术的冠心病病人128例,双盲法随机分为观察组和对照组各64例,在内科常规治疗基础上,观察组加服氟哌噻吨美利曲辛片,每天2次,对照组给予同样剂型的安慰剂.在治疗开始前、治疗后1、2、4周分别进行状态焦虑量表和17项汉密尔顿抑郁量表评定,并比较治疗后两组心脏有关的临床症状和体征.结果 观察组治疗后的焦虑评分和抑郁评分均呈显明显下降趋势,治疗后1、2、4周的焦虑评分和抑郁评分与治疗前比较均差异有统计学意义(P<0.05),且观察组在治疗后同一时间的焦虑评分和抑郁评分均低于对照组,均差异有统计学意义(P<0.05).术后观察组的心绞痛、心肌梗死、室性心动过速、室性早搏的发生率均低于对照组,均差异有统计学意义(P<0.05).结论 氟哌噻吨美利曲辛应用于PCI术后的冠心病病人,能显著减轻其焦虑抑郁情绪,并能改善预后.%Objective To evaluate the effects of Deanxit in the improvement of anxiety,depression and prognosis in post percutaneous coronary intervention(post-PCI)coronary heart disease patients.Methods A total of 128 coronary heart disease patients who under-went the PCI in this hospital were chosen,and randomly divided into observation group(64 cases)and control group(64 cases).Based on the routine treatment,cases in observation group were given Deanxit,2 times a day,and controls group were given placebo with the same dosage form.SAI scale and HAMD17 scale were conducted before treatment,and 1,2 and 4 weeks after treatment.The heart-relat-ed signs and symptoms between 2 groups were compared.Results The anxiety score and depression score in observation group after treatment decreased obviously,and had statistically significant difference between pre-treatment and 1 ,2 and 4 weeks after treatment (P<0.05).The anxiety score and depression score of observation group at the same time after treatment were lower than those of the control(P<0.05).The incidence of stenocardia,myocardial infarction,ventricular tachycardia and ventricular premature beat in obser-vation group were lower than those of control group(P<0.05).Conclusions Deanxitcanobviouslyalleviatepost-PCIanxietyand depression in coronary heart disease patients,and improve prognosis.