脑心通联合尼莫地平治疗血管性痴呆的临床研究

摘要

目的 分析脑心通胶囊联合尼莫地平治疗血管性痴呆(vascular dementia,VD)的疗效.方法 将入选的76例血管性痴呆患者分为联合用药组40例,尼莫地平组36例.尼莫地平组在常规治疗的同时给予尼莫地平片30 mg口服,每日3次;联合用药组在此基础上加用步长脑心通4粒/次口服,每日3次,疗程均为3个月.结果 两组治疗后临床症状明显缓解且联合用药组优于尼莫地平组(总有效率95% vs 65%,P＜0.01);精神量表评定,联合用药组患者接受治疗后,简易精神智能状态评估量表(MMSE)评分明显高于同组治疗前及尼莫地平组治疗后(均P＜0.01),日常生活能力量表(ADL)评分,联合用药组与尼莫地平组治疗后均低于治疗前(均P＜0.01),且联合用药组治疗后ADL评分较尼莫地平组下降更明显(P＜0.01).结论 脑心通胶囊联合尼莫地平治疗VD疗效优于单用尼莫地平.%Objective To study the clinical effect of combined treatment of Naoxintong with nimodipine for vascular dementia(VD). Methods Seventy-six cases of VD were randomly divided into 2 groups:combination therapy group(40 cases)and nimodipine group(36 cases). On the basis of routine treatment, nimodipine group was given nimodipine(30 rog, three times a day),and combination therapy group given nimodipine(30 mg,three times a day)and Buchang Naoxintong(four capsules, three times a day). The treatment course was three months. Results The symptoms of VD were greatly improved by the combined treatment of Naoxintong with nimodipine, and combination therapy group was more effective than nimodipine group(95％ vs 65％ ,P＜0.01). MMSE score in combination therapy group was higher than that before treatment and nimodipine group(P＜ 0.01). ADL score in combination therapy group and nimodipine group was lower than that before treatment(P＜0.01) ,and that in combination therapy group was lower than in nimodipine group. Conclusion It is effective to treat VD with Naoxintong com bined with nimodipine.