胆囊切除与结直肠腺瘤的相关性研究

摘要

Objective To explore the correlation between cholecystectomy and colorectal adenoma.Methods A total of 981 patients who underwent colonoscopy between January 2007 to December 2012 at Wuhan Central Hospital were enrolled in the study according to the inclusion criteria.The patients were divided into cholecystectomy group (n=216) and control group(n=765) in terms of cholecystectomy or not.The incidence of colorectal adenoma ,gender ,age ,location and pathological type of ade-noma were analyzed in the two groups.Results Significant differences were noted in the incidence and location of colorectal ad-enoma ,and gender between the two groups (P< 0.05).The incidence of colorectal adenoma was higher in cholecystectomy group than in control group ;the number of female patients with colorectal adenoma was greater than that of male patients ;the incidence of proximal colorectal adenoma was higher than that of distal adenoma.But the average age of patients with adenoma was not significantly associated with the pathological types of adenoma in both groups (P>0.05).Conclusion Cholecystecto-my is closely associated with the occurrence of colorectal adenoma.Screening for colorectal adenoma should be considered in the patients with gall bladder removal.%目的：研究胆囊切除与结直肠腺瘤的相关性。方法按纳入标准收集并整理分析武汉市中心医院2007年1月至2012年12月行结肠镜检查的患者981例。根据患者既往有无胆囊切除史分为胆囊切除组（n＝216）和对照组（n＝765），对两组患者结直肠腺瘤的检出率及腺瘤患者性别、年龄、腺瘤发生部位、病理分型进行统计学分析。结果两组结直肠腺瘤的检出率以及两组腺瘤患者的性别、腺瘤发生部位有显著差异（P＜0.05），胆囊切除组腺瘤检出率高于对照组，女性腺瘤患者多于男性，近端大肠腺瘤多于远端；但两组腺瘤患者的平均年龄及腺瘤病理分型差异无统计学意义（P＞0.05）。结论胆囊切除与结直肠腺瘤的发生密切相关，因此对有胆囊切除史的患者应重视对结直肠腺瘤的筛查。