Bioactive Surface Gradients to Control Cell Adhesion

摘要

A truly "universal substrate" for bioactive species functionalization provides a versatile tool to probe biological hypotheses where ligand concentration and orientation are important. Peptide functionalized gradient substrates have shown the ability to control cell adhesion and therefore provide a tool for screening surface directed cell function. Furthermore, this work extends the NIST combinatorial approach for materials characterization to an investigation of cell-material interactions.