Quantitative measurement of the serum C reactive protein in different clinic categories of late spontaneous and therapeutic abortion

摘要

The goal of our prospective and controlled study was to dose the serum C reactive protein by Tina-quant immunoturbidimetric technique in parallel with leukocytes counting, in case of patients in the second gestational trimester with threatened abortion of unknown cause, that did or did not evolve towards spontaneous abortion during hospitaiization, or with recurrent abortions in their priors, or with subclinical chorioamnionitis with or without broken membranes, or hospitalized for medical induction of the abortion for fetal reasons (such as retained dead fetus), or with acute pyelonephritis, subclinical mixed vaginitis or areolar mammary abscess, or with a normal pregnancy. Our results constantly indicate a significant (more accentuated after exogenous administration of pro stag landins in induced abortion) and maximum increase of serum CRP concentration (but not of the leukocytes number) at 24 hours postabortum, followed by a progressive decrease, of minimum 18%, of the same parameter, at 48 hours after non complicated second trimester abortion. Only the pregnancy complicated with high urogenital bacterial infections is accompanied by pathological values of the serum CRP (but not of the leukogram) that are significantly increased with respect to those from a normal pregnancy or one complicated with threatened abortion of unknown and non evolutive cause, or recurrent abortions in history. The obtained results suggest that a repeated measurement of the serum CRP concentration could be a valuable predictive marker for intrauterine infection, both in the late periabortum period as well as in the latency phase of the extremely premature rupture of the membranes or even when the fetal membranes are intact in the second trimester