Regulation of ATP Supply in Muscle: Implications for Importance of Flux Control Coefficients and for the Genesis of Mitochondrial Myopathies

摘要

There is a huge increase in the demand for ATP during exercise of skeletal muscle, and the rate of ATP production by oxidative phosphorylation must be adjusted in some way to meet the increased energy demand. Different mechanisms of an adequate activation of respiration in mitochondria have been proposed. According to the traditional view (Chance & Williams, 1955), an intracellular messenger (Ca~(2+)) only activates directly ATP usage (mainly actomyosin-ATPase), various steps of the ATPproducing system being activated indirectly via changes in the ATP/ADP ratio and the concentrations of other metabolites.