Dynamic properties of different kinds of nanoparticles in mouse model after intravenous administration

摘要

Nanoparticles have a promising application prospect in biomedical field. The study of their dynamic characteristics including in vivo distribution and clearance has the most important significance on their biological application. In this paper, bio-distribution and clearance of solid and colloid nanoparticles with different size in mouse model was intensively studied in vivo by using near infrared optical imaging technique. Here, nanohydrogels were synthesized by precipitation polymerization method and the size of the nanohydrogel could be arbitrarily manipulated according to different surfactant concentration. Near infrared fluorescence dye were entrapped into their inner core for in vivo studies. Meanwhile, the size of CdHgTe/Si02 solid nanoparticles could be controlled by the thickness of Si02 coated on the surface of CdHgTe. The results from the near infrared imaging showed that nanohydrogels with different size have the similar tissue distribution but CdHgTe/Si02 nanoparticles in different size have a size-dependent organ specification. These results provided an important reference for the design of targeted drug delivery systems and their biomedical applications.