SOLID NANOPARTICLE FORMULATION OF WATER INSOLUBLE PHARMACEUTICAL SUBSTANCES WITH REDUCED OSTWALD RIPENING AND IMMEDIATE DRUG RELEASE FOLLOWING INTRAVENOUS ADMINISTRATION

摘要

The present invention provides a composition comprising solid nanoparticles wherein the solid nanoparticles comprise i) an effective amount of a first therapeutically active agent; ii) an effective amount of one or more additional therapeutically active agents; and iii) a biocompatible polymer wherein the one or more additional therapeutically active agents is sufficiently miscible with the first therapeutically active agent to form solid particles, wherein the particles comprise a substantially single-phase mixture of the first therapeutically active agent and the one or more additional therapeutically active agents.