Spectropolarimetric comparison of molecular-genetic study of BRCA1 gene mutation types in patients with breast cancer and their relatives

摘要

This work is devoted to the substantiation and selection of patients with breast cancer (BC) for the purpose ofconducting expensive molecular genetic studies on genotyping. As diagnostic methods have been used ultravioletspectrometry samples of blood plasma in the liquid state, infrared spectroscopy middle range (2,5 - 25 microns)dry residue of plasma polarization and laser diagnostic technique of thin histological sections of biologicaltissues. Obtained results showed that the use of spectrophotometry in the range of 1000-3000 cm~(-1) allowed toestablish quantitative parameters of the plasma absorption rate of blood of patients in the third group in differentranges, which would allow in the future to conduct an express analysis of the patient's condition (procedurescreening) for further molecular-genetic typing on BRCA Ⅰ and Ⅱ.