Effect of Boiled Water Parasite Kapok (Dendrophthoe pentandra) Leaves on Total Cholesterol Levels and Histopathology of Hepar of Hypercholesterolemic Mice

摘要

This study aims to determine effect of boiled water parasite kapok (Dendrophthoe pentandra) leaves on the total cholesterol level and histopathology of hepar of hypercholesterolemic mice (mus musculus). This study used 20 ICR male mice divided into 4 treatment groups namely normal mice group, hypercholesterolemic mice group, mice group with boiled water kapok parasite at a dose of 400 mg/kg BW, and 800 mg/kg BW, respectivelly. The animal group was given boiled water kapok parasite after standard feeding and cholesterol feed for 2 weeks. The parameters observed in this study were total cholesterol levels, the amount of fat granules in the liver tissue of mice which were observed in the form of liver-preserved preparations made by paraffin method. The results showed that the administration of parasitic kapok (Dendrophthoe pentandra) at a dose of 400 mg/kg BW and 800 mg/kg BW had an effect on decreasing the total cholesterol level of mice and the histopathology of hepar of showed improvement after the therapy.