Drugs Interaction in Clinical Management for (Generalized Anxiety Disorders) Inpatients: A Retrospective Study

摘要

GAD (Generalized anxiety disorder) or Comprehensive Anxiety Disorder is a feeling of severe anxiety that is persistent, accompanied by somatic symptoms that cause social function and work function disorders. GAD patients often get more than two types of drugs thereby increasing the likelihood of drug interactions. The mechanism of drug interactions is divided into pharmacokinetics and pharmacodynamics. This study was aimed to investigate the potential for drug interactions and management of drug interaction events so it was able to minimize the incidence of drug interaction in GAD patients in YANKESWA Banyumas Regional Hospital by providing rational therapy. The method of this research was a retrospective observational study. Data were analyzed descriptively using Stockley's Drug Interaction, Drug Interaction Facts and www.drugs.com database. The results revealed that of 47 GAD patients, there were 89.36% incidence of drug interactions, with pharmacodynamic interactions dominating 68.57% compared to pharmacokinetics 31.42%. The most common interaction is the interaction between sertraline and alprazolam.