An efficient synthesis of novel anti influenza viral and cytotoxic derivatives of 4-oxothiazolidin-3-yl)-3-hydroxyquinoxaline-2-carboxamide

摘要

Quinoxalines, especially, 3-methoxy and 2-furyl substituted quinoxalines, designed to imitate Epigallocatechin-3-gallate are capable of inhibiting the growth of influenza-A virus. It is essential to design new derivatives which are anti-influenza viral agents in the present scenario. Quinoxaline carboxamides are cytotoxic agents that are useful for treating various cancers. As carrier ligands they can replace ligands of the platinum (II) compounds such as cisplatin. Cisplatin is a familiar platinum containing anticancer drug, but it is toxic to renal tubules that harm the renal function. Studies reveal that, the toxic nature of cisplatin is checked by a product containing oxathiazolidine moiety such as L-2-oxothiazolidine-4-carboxylic acid. Considering the significance of the two moieties quinoxaline and oxathiazolidine, following new 4-oxothiazolidin-3-yl)-3-hydroxyquinoxaline-2-carboxamide derivatives were synthesized and their structures were confirmed by using H1NMR and LCMS.