Synthesis of Oligosaccharide derived from Pathogenic E.coli UsingBoronic-Acid-Catalyzed Regio-and Stereoselective β-Rhamnosylation

摘要

Pathogenic Escherichia coli (E.coli) O1 is the common bacterial pathogen infectingchickens,leading to substantial economic losses in the poultry industry worldwide.In addition,pathogenic E.coli O1 stains have zoonotic potential.Therefore,to elucidate of the minimalglycan epitopes of pathogenic E.coli O1 and develop the glycovaccines,the chemical synthesisof homogeneous and structurally well-defined partial oligosaccharides and theirglycoconjugates have attracted much attention.Herein,we report the efficient synthesis ofcomplex oligosaccharide derived from pathogenic E.coli O13) and its glycoconjugate usingrecently developed our boronic-acid-catalyzed regio-and stereoselective β-rhamnosylation asa key step.