Selective hydrogenation of quinoline by PdRuPVP catalyst under mild reactionconditions

摘要

Selective hydrogenation of arene transforms aromatic substrate to saturated carbo-andheterocycles.The utilization of arene hydrogenation in fine chemical sector is gaining attentionfor the synthesis of saturated functional molecules,e.g.selective hydrogenation of quinoline to1,2,3,4-tetrahydroquinolines.1,2,3,4-tetrahydroquinolines are one of the important biologicalactive molecules which are used for the synthesis of drugs,agrochemicals,dyes.Catalytichydrogenation of quinolines is a direct and efficient route to the synthesis of 1,2,3,4-tetrahyydroquinolines.Several catalytic methods have been reported by using heterogeneous (Pd,Rh,Ru,Au and Co) catalysts using high temperature (>80 °C) and pressure (>10 bar).At roomtemperature,homogeneous (Ir) and heterogeneous (Pt) catalysts were studied for hydrogenationof quinolines using high pressure (>20 bar).However,these catalysts methods require hightemperature and/or high pressure.