Characterization of Rheological Property of Mucoadhesive Polymeric Sol-Gel in the Presence of Black Ginger Kaempferia parviflora Extract

摘要

The local drug delivery based on mucoadhesion is an effective medical treatment. The mucoadhesive property relies on the formulated gel having optimized rheology. The addition of the drug also showed a major influence towards the sol-gel transition. In this study, compositional effect of Eudragit E100? base polymer, various mucoadhesive polymers, and the black ginger extract on the rheological property of the formulated sol-gel was assessed. It was found that gelling point and gel strength could be tuned mainly based on the concentration of Eudragit E100 limited at 40% w/w due to the viscosity. At Eudragit E100 of 30% w/w, 0.5% w/w herbal extract, and 1%w/w polyvinyl alcohol, the solution reached the gel point at 286 s (tan 5=1) with the gel strength of 1 kPa (G'=G”). For all the formulated sol-gels, the rheological property became better (faster gelling point with the gel strength varying from 100-700 kPa at low strain) a simulated saliva environment.