Diagnostic Value of Ki67 mRNA Levels: Quantitative Analysis of Ki67 mRNA in Formalin-Fixed- Paraffin-Embedded Cervical Cancer Tissues

摘要

Cervical cancer is the third most common cancer in women. The main cause of cervical cancer is known to be the persistent infection of high risk human papillomavirus (HR-HPV). For this reason, molecular tests for HR-HPV detection have been used together with conventional pathological tests in clinical settings for cervical cancer diagnosis. However, it has been reported that 10 to 15% of cervical cancer specimens are negative to HR-HPV tests. Therefore, in order to improve the sensitivity of cervical cancer diagnosis based on HR-HPV detection, it seems necessary to find additional novel biomarker which can complement the HR-HPV test results. Ki67 is known to be a cell proliferation marker whose activation leads to cervical cancer progression, and thus the Immunohistochemical test targeting Ki67 protein has been widely used for cervical cancer diagnosis in clinical practice.