Use of HPV E6/E7 and hTERT mRNA RT-qPCR Assays in Combination for Diagnosing High Grade Cervical Lesions

摘要

Human papillomavirus (HPV) is a major cause of cervical cancer, which is the third most common cancer in women. HPV E6 oncoprotein initiates degradation of cellular tumor suppressor protein p53, and induces human telomerase reverse transcriptase (hTERT) activity. Activation of hTERT then leads to progressive cervical carcinogenesis.