l-stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates methamphetamine self-administration in rate

摘要

Given the problems associated with the escalation in methamphetamine (METH) use, the identification of more effective treatment strategies is essential, l-stepholidine (l-SPD) is an alkaloid extract of the Chinese herb Stephania intermedia with dopamine Dl receptor partial agonistic and D2 receptor antagonistic dual actions. The unique pharmacological profile of l-SPD suggests that l-SPD may be effective for the treatment of METH addiction. The aim of this study was to characterize the effect ofl -SPD on METH self-administration on a fixed-ratio 1 schedule. We found that 5 and 10 mg/kg of l-SPD attenuated METH self-administration behavior. These results demonstrate that l-SPD which possesses dual actions on dopamine Dl and D2 receptors, attenuates METH self-administration on a fixed-ratio 1 schedule.