Optoelectronic method for determinating the selective serotonin reuptake inhibitors antidepressants

摘要

Mass spectrometry is an optoelectronic method of identifying organic substances by comparing their mass spectrum of the analyte with the mass spectra deposited in the mass spectrum libraries of the system. High Pressure Liquid Chromatography (HPLC) coupled with Mass Spectrometry (MS) has as main objective the identification of drugs with a molecular molecule of less than 1500 amu (atomic mass units) [1]. To identify the biological products of antidepressants SSRIs have been deposited in the mass-spectra of the MI library, mass spectra obtained in a HPLC-MS interface with ElectroSpray Interface (ESI) or Atmospheric Pressure Chemical Ionization (APCI). In the paper are presented the mass spectra of selective serotonin reuptake inhibitors (SSRIs): citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine and sertraline, obtained on a HPLC system MS equipped with ESI or APCI.