Synthesis and Characterization of PEG-PBS Copolymersto Obtain Microspheres With Different NaproxenRelease Profiles

摘要

Researching for new biomaterials intended for drug delivery systems hasconsiderably intensified in recent years. There is an increasing interest inPBS (poly[butylene succinate]) and its copolymers as biomaterials due to thepossibility of synthesis of the PBS from a renewable source. Among thesecopolymers, PBS-PEG (poly[butylene succinate-co-polyethylene glycol]) isstudied for materials that have shape memory and are biodegradable.However, to date, no research into the use of PBS-PEG to preparemicrospheres for drugs release has been reported. Herein, PBS-PEGs withthree PEG with different chain0s length were synthesized by polycondensationreaction and characterized by means of SEC, FTIR, DSC, TGA, and DRX.Naproxen loaded microspheres were prepared by an oil-in-water (o/w) singleemulsion technique. The drug release was followed by UV-Vis. The presenceof PEG had a marked effect on the in vitro release profiles. The mathematicalmodels employed show that the fundamental mechanism of release isdiffusion when PEG is present in the polymer matrix of the particle.