Synthesis and Evaluation of Titanium Oxide Modified Mussel Inspired Nanoparticles for Synergetic Photothermal and Photodynamic Effect

摘要

Applying two therapeutical modality using one system is primordial for enhanced treatment efficiency and decreased side effects. The main objective of this work was to develop polydopamine (PDA) based hybrid nanoparticles with strong near infrared absorbance and good NIR to heat conversion efficiency. The results proved successful preparation of polydopamine nanoparticles (PDNS) decorated with metal oxide (TiO2), spherical shaped of ~268 run mean diameter and negative surface charge (ζ=-16.40 mV). The prepared PDNS@TiO2 were characterized by FT-IR, UV-Vis, TEM and XPS. They exhibit a good thermal stability and significant photothermal conversion efficiency (η=34.9%). On other hand ESR spectra proves the ability of this kind of nanostructures to generate of ROS under UV irradiation due to the presence of TiO2 on the surface. This paper describes the design and evaluation of novel nanostructures for combined photothermal and photodynamic effect. A remarkable synergistic therapeutic effect has been achieved compared with respective single treatments. This work suggests that the PDA-based nanoplatform can be a universal scaffold for single or combined therapy.