One Pot Green Synthesis of a-Aminophosphonates with D-Malic Acid as an Organocatalyst

摘要

A one pot multi-component reactions using D-Malic acid as a chiral organocatalyst was carried out to synthesize a series of a-aminophosphonates by the reaction of various aldehydes, aniline and diethyl phosphite under solvent free conditions in excellent yield and were compared to parallel reactions under same conditions in absence of catalyst. The compounds thus synthesized were analyzed through NMR. The obtained outcomes represents excellent results with the used catalyst signifying that D-malic acid could be a persuasive catalyst for certain organic synthesis.