Mixed RNA duplexes, a new type of nucleic acid inhibit A549 cell linegrowing

摘要

A new type of nucleic acid (mixed RNA, mixRNA) that shared the activity of siRNA was put forward. The mixRNA duplexes contain RNA or DNA elementary units but contain no RNA or DNA segments. The new type of mixRNA duplexes inhibited cell proliferationin A549 cell line (a human lung cancer cell line) in a concentration-dependent manner. Since the mixRNA was theoretically resistant to DNase and RNase, mixRNA could be a new tool for scientific research and for clinic therapy.