Novel Mercaptan Derivatives Nanogold Particles with Hyperchromic and Fluorescence Sensitization Effects

摘要

Carcinoembryonic antigen (CEA), typically associated with certain tumors is widely used as clinical tumor markers for diagnosing certain cancers and hence its detection is of great essence in clinical diagnostics. A large number of surface atoms of nanoparticles have huge surplus bonding ability, because of the surface effect of gold nanoparticles, resulting in reuniting and sinking among the nanoparticles which makes them unstable. However, for effective and efficient bioassay, a stable nanomaterial with good hyperchromic and fluorescence sensitization effects is of essence. In order to detect traces of CEA, a new kind of nanomaterial with hyperchromic and fluorescence sensitization effects is considered essential. In this paper, a new kind of mercaptan derivatives nanogold (MDN) particles is studied using ultraviolet-visible absorption spectra (UV-vis), fluorescence emission spectrum method. The prepared nanogold and MDN, was interacted with carcinoembryonic antigen (CEA). It was observed that the interaction between MDN and CEA had good hyperchromic and fluorescence sensitization effects. Given its promising advantage, it is expected that this nanomaterial with hyperchromic and fluorescence sensitization effects will be an attractive tool for use in many different fields.