Malignancy Prediction of Gastrointestinal Stromal Tumors by Evaluating Tumor Vessel Density from Enhanced Spiral CT Scan

摘要

Purpose The aim of this study was to evaluate the role of tumor blood vessel density from enhanced spiral CT Scan in the malignancy prediction of small bowel gastrointestinal gist tumors (GISTs). Methods Altogether twenty five cases of small bowel GISTs were included. The malignancy grade was classified as benign small bowel stromal tumors (BSS), uncertain malignant potential small bowel stromal tumors (UMPSS), and malignant small bowel stromal tumors (MSS). All the patients received enhanced abdominal CT, and three dimensional imaging of tumor blood vessels were constructed based on the enhanced CT examination, which were input and measured by a software system measure the tumor vessel density (TVD). Results Significant TVD difference was found among the three group (P=0.000), and significant difference was also found between BMS and UPMSS, BMS and MSS, UPNSS and MSS group. (P=0.016, P=0.011, and P=0.038 respectively). TVD level in Ki - 67 positive group is significantly higher than that of Ki - 67 negative group (P= 0.011). Conclusion This study suggested that preoperative measurement of TVD from enhanced three dimensional CT scan can help predict the malignancy extent of small bowel GISTs.