Pathological effects of the renin-angiotensin system on cardiovascular disease

摘要

the renin-angiotensin system (RAS) found in a research as a new member, changes the past view that only the angiotensin (Ang) Ⅱ catalyzed by angiotensin-converting enzyme (ACE) can produce pathogenic role. The research proved the renin binding with former prime renin - receptor (RPR) and Ang Ⅳ binding with insulin receptor regulated aminopeptidase (IRAP) will also produce the same pathogenic role. The newly discovered ACE2 catalyzes Ang-(1-7) and Ang-(1-9) generation, then the receptor of Ang-(1-7) and Mas and the receptor of Ang-(1-9) and AT2 binding, may produce cardiovascular protective effect, but the pathogenic role of RAS is still dominant. The discovery of RAS new member provides a new theoretical basis to recognize RAS inhibitors in clinical research results.