MULTIDISCIPLINARY APPROACH TO ONCOLOGIC DISEASES. PERSPECTIVES FROM AN ONCOLOGIST, A SURGEON AND A PATHOLOGIST. INTRAABDOMINAL TUMOR: FELINE GASTROINTESTINAL LYMPHOMA

摘要

The goal of this lecture is to provide a multidisciplinary approach to the diagnosis, staging, treatment and prognosis associated with feline gastrointestinal neoplasia, specifically lymphoma, in a case based manner. This overview will specifically highlight the input of a medical oncologist, clinical pathologist and surgeon.Lymphoma (LSA) is the not only the most common neoplasia in cats (-25%) but also the most common hematopoietic malignancy in this species, with the gastrointestinal form representing nearly 80% of cases. Since lymphoma is often considered a "liquid cancer", combination chemotherapy is standard of care and can lead to complete remission rates of approximately 30-65%, with a median duration of remission of 3-7 months.The paradigm of LSA has changed, as this is no longer a virally induced cancer in the majority of patients. A percentage of FeLV positive cats will develop lymphoma during their lifetime, typically at a younger age, the anatomic location of the mediastinum and often associated with a poorer prognosis. With the advent of more routine vaccinations, FeLV induced LSA has diminished remarkably. More recent factors that may play a role in the development of LSA include breed, environmental exposures (tobaccosmoke), altered immune system function including that associated with organ transplantation and potentially inflammatory bowel disease.