Investigation of Adsorption/Release Process of Promethazine Hydrochloride on Synthetic Zeolites

摘要

Promethazine Hydrochloride (PTZ) is an antihistaminic drug widely used in various clinical applications. Due to the fact that PTZ is oxygen sensitive, in many applications it needs to be loaded into an insoluble matrix. Among the drug loading and release matrix, synthetic zeolite 13X is one of the most suitable. In this paper, we performed a study for the drug adsorption/release, using a zeolite matrix. The drug adsorption/release studies have been performed for different PTZ concentrations and different amount of zeolite, using UV-Vis spectroscopy. Langmuir and Freundlich adsorption isotherms were used to correlate the equilibrium adsorption data. Pseudo-first and pseudo-second order kinetic models were applied to describe the adsorption process. The adsorption yield was calculated to be 61.76%. Freundlich isotherm was found to be more suitable for describing the adsorption-desorption equilibrium data of PTZ into zeolites and the kinetic data fitted well the pseudo-second-order model.