In this paper, we have started from the point of view of bionics, doing surface bionic non-smooth design at the standard No.16 animal syringe needles. Then treating the concave as the bionic unit, we worked out the concave bionic drag reduction needles by use of the laser material remove processing means. In accordance with the national standard on the injection drag test of disposable needles, we did the puncture drag comparative test of the smooth needles and the bionic needles, getting the correspondence relationship between the drag reduction rate and the bionic unit parameters. We found that the maximum drag reduction rate up to 44.05%, and it appeared when the concave interval was 0.9mm and the concave diameter was 0.09mm. Then through discussing the drag reduction mechanism of the bionic needles, we knew that the bionic units reduced the actual contact area between the needle outer wall and the simulation skin, and it was the main reason of bionic needles puncture drag decreases.
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