Many anti-glaucoma eyedrops are reported to cause CME in aphakia and pseudophakia. We review our 2 clinical studies that compare the incidence of CME in early postoperative pseudophakic eyes that received preserved latanoprost and timolol, nonpreserved timolol, and the preserved and nonpreserved vehicle for these drugs. We have also carried out a laboratory study using lens epithelial cells in culture to look at the morphological damage to cells and the changes in the indicators of cytokine and PG synthesis caused by latanoprost and timolol and the preservative benzalkonium chloride. Based on the findings of these studies, which indicate that the preservative causes increased synthesis of PGs and other inflammatory mediators, and intensified postoperative inflammation, the term pseudophakic preservative maculopathy is proposed for CME caused by anti-glaucoma eyedrops.
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